Using 3D-printing to fabricate a microfluidic vascular model to mimic arterial thrombosis

H.J. Albers; J.E.A. Linssen; P.F. Costa; H.H.T. Middelkamp; L. van der Hout; J. Malda; R. Passier; A. van den Berg; A.D. van der Meer

Using 3D-printing to fabricate a microfluidic vascular model to mimic arterial thrombosis

H.J. Albers^*
, J.E.A. Linssen
, P.F. Costa
, H.H.T. Middelkamp
, L. van der Hout
, J. Malda
, R. Passier
, A. van den Berg
, A.D. van der Meer

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic

Abstract

Vascular microfluidic models were manufactured using stereolithography and soft lithography based on computed tomography angiography data. These microfluidic chips were lined with endothelial cells and the devices could be perfused with human whole blood at arterial shear rates. When comparing healthy and stenotic geometries the healthy geometries showed no sign of platelet aggregation, while stenotic geometries showed platelet aggregation near and distal of the stenotic apex.

Original language	English
Title of host publication	21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Publisher	The Chemical and Biological Microsystems Society
Pages	1070-1071
Number of pages	2
ISBN (Electronic)	9780692941836
Publication status	Published - 1 Jan 2020
Event	21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2017 - Savannah International Trade & Convention Center, Savannah, United States Duration: 22 Oct 2017 → 26 Oct 2017 Conference number: 21 https://www.microtas2017.org/

Conference

Conference	21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2017
Abbreviated title	MicroTAS
Country/Territory	United States
City	Savannah
Period	22/10/17 → 26/10/17
Internet address	https://www.microtas2017.org/

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 9 Industry, Innovation, and Infrastructure

Keywords

3D-printing
Arterial
Organ-on-chip
SLA
Thrombosis
Vasculature

Cite this

Albers, H. J., Linssen, J. E. A., Costa, P. F., Middelkamp, H. H. T., van der Hout, L., Malda, J., Passier, R., van den Berg, A., & van der Meer, A. D. (2020). Using 3D-printing to fabricate a microfluidic vascular model to mimic arterial thrombosis. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 1070-1071). The Chemical and Biological Microsystems Society.

@inproceedings{1093eb783bb748ad9ef540a3ad9e1418,

title = "Using 3D-printing to fabricate a microfluidic vascular model to mimic arterial thrombosis",

abstract = "Vascular microfluidic models were manufactured using stereolithography and soft lithography based on computed tomography angiography data. These microfluidic chips were lined with endothelial cells and the devices could be perfused with human whole blood at arterial shear rates. When comparing healthy and stenotic geometries the healthy geometries showed no sign of platelet aggregation, while stenotic geometries showed platelet aggregation near and distal of the stenotic apex.",

keywords = "3D-printing, Arterial, Organ-on-chip, SLA, Thrombosis, Vasculature",

author = "H.J. Albers and J.E.A. Linssen and P.F. Costa and H.H.T. Middelkamp and \{van der Hout\}, L. and J. Malda and R. Passier and \{van den Berg\}, A. and \{van der Meer\}, A.D.",

year = "2020",

month = jan,

day = "1",

language = "English",

pages = "1070--1071",

booktitle = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017",

publisher = "The Chemical and Biological Microsystems Society",

note = "21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2017, MicroTAS ; Conference date: 22-10-2017 Through 26-10-2017",

url = "https://www.microtas2017.org/",

}

Albers, HJ, Linssen, JEA, Costa, PF, Middelkamp, HHT, van der Hout, L, Malda, J, Passier, R , van den Berg, A & van der Meer, AD 2020, Using 3D-printing to fabricate a microfluidic vascular model to mimic arterial thrombosis. in 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017. The Chemical and Biological Microsystems Society, pp. 1070-1071, 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2017, Savannah, Georgia, United States, 22/10/17.

Using 3D-printing to fabricate a microfluidic vascular model to mimic arterial thrombosis. / Albers, H.J.; Linssen, J.E.A.; Costa, P.F. et al.
21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017. The Chemical and Biological Microsystems Society, 2020. p. 1070-1071.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Academic

TY - GEN

T1 - Using 3D-printing to fabricate a microfluidic vascular model to mimic arterial thrombosis

AU - Albers, H.J.

AU - Linssen, J.E.A.

AU - Costa, P.F.

AU - Middelkamp, H.H.T.

AU - van der Hout, L.

AU - Malda, J.

AU - Passier, R.

AU - van den Berg, A.

AU - van der Meer, A.D.

N1 - Conference code: 21

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Vascular microfluidic models were manufactured using stereolithography and soft lithography based on computed tomography angiography data. These microfluidic chips were lined with endothelial cells and the devices could be perfused with human whole blood at arterial shear rates. When comparing healthy and stenotic geometries the healthy geometries showed no sign of platelet aggregation, while stenotic geometries showed platelet aggregation near and distal of the stenotic apex.

AB - Vascular microfluidic models were manufactured using stereolithography and soft lithography based on computed tomography angiography data. These microfluidic chips were lined with endothelial cells and the devices could be perfused with human whole blood at arterial shear rates. When comparing healthy and stenotic geometries the healthy geometries showed no sign of platelet aggregation, while stenotic geometries showed platelet aggregation near and distal of the stenotic apex.

KW - 3D-printing

KW - Arterial

KW - Organ-on-chip

KW - SLA

KW - Thrombosis

KW - Vasculature

UR - https://www.scopus.com/pages/publications/85079601473

M3 - Conference contribution

AN - SCOPUS:85079601473

SP - 1070

EP - 1071

BT - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

PB - The Chemical and Biological Microsystems Society

T2 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2017

Y2 - 22 October 2017 through 26 October 2017

ER -

Using 3D-printing to fabricate a microfluidic vascular model to mimic arterial thrombosis

Abstract

Conference

UN SDGs

Keywords

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Cite this