Using Oblivious RAM in Genomic Studies

Nikolaos P. Karvelas, Andreas Peter, Stefan Katzenbeisser

    Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review


    Since the development of tree-based Oblivious RAMs by Shi et al. it has become apparent that privacy preserving outsourced storage can be practical. Although most current constructions follow a client-server model, in many applications, such as Genome Wide Association Studies (GWAS), it is desirable that multiple entities can share data, while being able to hide access patterns not only from the server, but also from any other entities that can access parts of the data. Inspired by the efficiency and simplicity of Path-ORAM, in this work, we study an extension of Path-ORAM that allows oblivious sharing of data in a multi-client setting, so that accesses can be hidden from the server and from other clients. We address various challenges that emerge when using Path-ORAM in a multi-client setting, and prove that with adequate changes, Path-ORAM is still secure in a setting, where the clients are semi-honest, do not trust each other, but try to learn the access patterns of each other. We demonstrate our ORAM construction in a GWAS setting. Our experiments show that in databases storing 223 data blocks (corresponding to a database holding 217 blocks per client, capable of storing human genome in the form of SNPs, for 100 clients), the average query time is less than 7 s, yielding a secure and practical solution.
    Original languageEnglish
    Title of host publicationData Privacy Management, Cryptocurrencies and Blockchain Technology
    Subtitle of host publicationESORICS 2017 International Workshops, DPM 2017 and CBT 2017, Oslo, Norway, September 14-15, 2017, Proceedings
    EditorsJoaquin Garcia-Alfaro, Guillermo Navarro-Aribas, Hannes Hartenstein, Jordi Herrera-Joancomarti
    ISBN (Electronic)978-3-319-67816-0
    ISBN (Print)978-3-319-67815-3
    Publication statusPublished - 2017
    Event22nd European Symposium on Research in Computer Security, ESORICS 2017 - Oslo, Norway
    Duration: 11 Sep 201715 Sep 2017
    Conference number: 22

    Publication series

    NameLecture notes in computer science


    Conference22nd European Symposium on Research in Computer Security, ESORICS 2017
    Abbreviated titleESORICS


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