Using the NEMA NU 4 PET image quality phantom in multipinhole small-animal SPECT

A.A. Harteveld, A.P.W. Meeuwis, J.A. Disselhorst, Cornelis H. Slump, W.J.G. Oyen, O.C. Boerman, E.P. Visser

    Research output: Contribution to journalArticleAcademicpeer-review

    19 Citations (Scopus)

    Abstract

    Several commercial small-animal SPECT scanners using multipinhole collimation are presently available. However, generally accepted standards to characterize the performance of these scanners do not exist. Whereas for small-animal PET, the National Electrical Manufacturers Association (NEMA) NU 4 standards have been defined in 2008, such standards are still lacking for small-animal SPECT. In this study, the image quality parameters associated with the NEMA NU 4 image quality phantom were determined for a small-animal multipinhole SPECT scanner. Methods: Multiple whole-body scans of the NEMA NU 4 image quality phantom of 1-h duration were performed in a U-SPECT-II scanner using 99mTc with activities ranging between 8.4 and 78.2 MBq. The collimator contained 75 pinholes of 1.0-mm diameter and had a bore diameter of 98 mm. Image quality parameters were determined as a function of average phantom activity, number of iterations, postreconstruction spatial filter, and scatter correction. In addition, a mouse was injected with 99mTc-hydroxymethylene diphosphonate and was euthanized 6.5 h after injection. Multiple whole-body scans of this mouse of 1-h duration were acquired for activities ranging between 3.29 and 52.7 MBq. Results: An increase in the number of iterations was accompanied by an increase in the recovery coefficients for the small rods (RCrod), an increase in the noise in the uniform phantom region, and a decrease in spillover ratios for the cold-air– and water-filled scatter compartments (SORair and SORwat). Application of spatial filtering reduced image noise but lowered RCrod. Filtering did not influence SORair and SORwat. Scatter correction reduced SORair and SORwat. The effect of total phantom activity was primarily seen in a reduction of image noise with increasing activity. RCrod, SORair, and SORwat were more or less constant as a function of phantom activity. The relation between acquisition and reconstruction settings and image quality was confirmed in the 99mTc-hydroxymethylene diphosphonate mouse scans. Conclusion: Although developed for small-animal PET, the NEMA NU 4 image quality phantom was found to be useful for small-animal SPECT as well, allowing for objective determination of image quality parameters and showing the tradeoffs between several of these parameters on variation of acquisition and reconstruction settings.
    Original languageUndefined
    Pages (from-to)1646-1653
    Number of pages8
    JournalJournal of nuclear medicine
    Volume52
    Issue number10
    DOIs
    Publication statusPublished - 17 Aug 2011

    Keywords

    • multi-pinhole
    • EWI-22996
    • Image quality
    • IR-83673
    • Small animal
    • Single photon emission computed tomography
    • NEMA

    Cite this

    Harteveld, A. A., Meeuwis, A. P. W., Disselhorst, J. A., Slump, C. H., Oyen, W. J. G., Boerman, O. C., & Visser, E. P. (2011). Using the NEMA NU 4 PET image quality phantom in multipinhole small-animal SPECT. Journal of nuclear medicine, 52(10), 1646-1653. https://doi.org/10.2967/jnumed.110.087114
    Harteveld, A.A. ; Meeuwis, A.P.W. ; Disselhorst, J.A. ; Slump, Cornelis H. ; Oyen, W.J.G. ; Boerman, O.C. ; Visser, E.P. / Using the NEMA NU 4 PET image quality phantom in multipinhole small-animal SPECT. In: Journal of nuclear medicine. 2011 ; Vol. 52, No. 10. pp. 1646-1653.
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    title = "Using the NEMA NU 4 PET image quality phantom in multipinhole small-animal SPECT",
    abstract = "Several commercial small-animal SPECT scanners using multipinhole collimation are presently available. However, generally accepted standards to characterize the performance of these scanners do not exist. Whereas for small-animal PET, the National Electrical Manufacturers Association (NEMA) NU 4 standards have been defined in 2008, such standards are still lacking for small-animal SPECT. In this study, the image quality parameters associated with the NEMA NU 4 image quality phantom were determined for a small-animal multipinhole SPECT scanner. Methods: Multiple whole-body scans of the NEMA NU 4 image quality phantom of 1-h duration were performed in a U-SPECT-II scanner using 99mTc with activities ranging between 8.4 and 78.2 MBq. The collimator contained 75 pinholes of 1.0-mm diameter and had a bore diameter of 98 mm. Image quality parameters were determined as a function of average phantom activity, number of iterations, postreconstruction spatial filter, and scatter correction. In addition, a mouse was injected with 99mTc-hydroxymethylene diphosphonate and was euthanized 6.5 h after injection. Multiple whole-body scans of this mouse of 1-h duration were acquired for activities ranging between 3.29 and 52.7 MBq. Results: An increase in the number of iterations was accompanied by an increase in the recovery coefficients for the small rods (RCrod), an increase in the noise in the uniform phantom region, and a decrease in spillover ratios for the cold-air– and water-filled scatter compartments (SORair and SORwat). Application of spatial filtering reduced image noise but lowered RCrod. Filtering did not influence SORair and SORwat. Scatter correction reduced SORair and SORwat. The effect of total phantom activity was primarily seen in a reduction of image noise with increasing activity. RCrod, SORair, and SORwat were more or less constant as a function of phantom activity. The relation between acquisition and reconstruction settings and image quality was confirmed in the 99mTc-hydroxymethylene diphosphonate mouse scans. Conclusion: Although developed for small-animal PET, the NEMA NU 4 image quality phantom was found to be useful for small-animal SPECT as well, allowing for objective determination of image quality parameters and showing the tradeoffs between several of these parameters on variation of acquisition and reconstruction settings.",
    keywords = "multi-pinhole, EWI-22996, Image quality, IR-83673, Small animal, Single photon emission computed tomography, NEMA",
    author = "A.A. Harteveld and A.P.W. Meeuwis and J.A. Disselhorst and Slump, {Cornelis H.} and W.J.G. Oyen and O.C. Boerman and E.P. Visser",
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    Harteveld, AA, Meeuwis, APW, Disselhorst, JA, Slump, CH, Oyen, WJG, Boerman, OC & Visser, EP 2011, 'Using the NEMA NU 4 PET image quality phantom in multipinhole small-animal SPECT', Journal of nuclear medicine, vol. 52, no. 10, pp. 1646-1653. https://doi.org/10.2967/jnumed.110.087114

    Using the NEMA NU 4 PET image quality phantom in multipinhole small-animal SPECT. / Harteveld, A.A.; Meeuwis, A.P.W.; Disselhorst, J.A.; Slump, Cornelis H.; Oyen, W.J.G.; Boerman, O.C.; Visser, E.P.

    In: Journal of nuclear medicine, Vol. 52, No. 10, 17.08.2011, p. 1646-1653.

    Research output: Contribution to journalArticleAcademicpeer-review

    TY - JOUR

    T1 - Using the NEMA NU 4 PET image quality phantom in multipinhole small-animal SPECT

    AU - Harteveld, A.A.

    AU - Meeuwis, A.P.W.

    AU - Disselhorst, J.A.

    AU - Slump, Cornelis H.

    AU - Oyen, W.J.G.

    AU - Boerman, O.C.

    AU - Visser, E.P.

    PY - 2011/8/17

    Y1 - 2011/8/17

    N2 - Several commercial small-animal SPECT scanners using multipinhole collimation are presently available. However, generally accepted standards to characterize the performance of these scanners do not exist. Whereas for small-animal PET, the National Electrical Manufacturers Association (NEMA) NU 4 standards have been defined in 2008, such standards are still lacking for small-animal SPECT. In this study, the image quality parameters associated with the NEMA NU 4 image quality phantom were determined for a small-animal multipinhole SPECT scanner. Methods: Multiple whole-body scans of the NEMA NU 4 image quality phantom of 1-h duration were performed in a U-SPECT-II scanner using 99mTc with activities ranging between 8.4 and 78.2 MBq. The collimator contained 75 pinholes of 1.0-mm diameter and had a bore diameter of 98 mm. Image quality parameters were determined as a function of average phantom activity, number of iterations, postreconstruction spatial filter, and scatter correction. In addition, a mouse was injected with 99mTc-hydroxymethylene diphosphonate and was euthanized 6.5 h after injection. Multiple whole-body scans of this mouse of 1-h duration were acquired for activities ranging between 3.29 and 52.7 MBq. Results: An increase in the number of iterations was accompanied by an increase in the recovery coefficients for the small rods (RCrod), an increase in the noise in the uniform phantom region, and a decrease in spillover ratios for the cold-air– and water-filled scatter compartments (SORair and SORwat). Application of spatial filtering reduced image noise but lowered RCrod. Filtering did not influence SORair and SORwat. Scatter correction reduced SORair and SORwat. The effect of total phantom activity was primarily seen in a reduction of image noise with increasing activity. RCrod, SORair, and SORwat were more or less constant as a function of phantom activity. The relation between acquisition and reconstruction settings and image quality was confirmed in the 99mTc-hydroxymethylene diphosphonate mouse scans. Conclusion: Although developed for small-animal PET, the NEMA NU 4 image quality phantom was found to be useful for small-animal SPECT as well, allowing for objective determination of image quality parameters and showing the tradeoffs between several of these parameters on variation of acquisition and reconstruction settings.

    AB - Several commercial small-animal SPECT scanners using multipinhole collimation are presently available. However, generally accepted standards to characterize the performance of these scanners do not exist. Whereas for small-animal PET, the National Electrical Manufacturers Association (NEMA) NU 4 standards have been defined in 2008, such standards are still lacking for small-animal SPECT. In this study, the image quality parameters associated with the NEMA NU 4 image quality phantom were determined for a small-animal multipinhole SPECT scanner. Methods: Multiple whole-body scans of the NEMA NU 4 image quality phantom of 1-h duration were performed in a U-SPECT-II scanner using 99mTc with activities ranging between 8.4 and 78.2 MBq. The collimator contained 75 pinholes of 1.0-mm diameter and had a bore diameter of 98 mm. Image quality parameters were determined as a function of average phantom activity, number of iterations, postreconstruction spatial filter, and scatter correction. In addition, a mouse was injected with 99mTc-hydroxymethylene diphosphonate and was euthanized 6.5 h after injection. Multiple whole-body scans of this mouse of 1-h duration were acquired for activities ranging between 3.29 and 52.7 MBq. Results: An increase in the number of iterations was accompanied by an increase in the recovery coefficients for the small rods (RCrod), an increase in the noise in the uniform phantom region, and a decrease in spillover ratios for the cold-air– and water-filled scatter compartments (SORair and SORwat). Application of spatial filtering reduced image noise but lowered RCrod. Filtering did not influence SORair and SORwat. Scatter correction reduced SORair and SORwat. The effect of total phantom activity was primarily seen in a reduction of image noise with increasing activity. RCrod, SORair, and SORwat were more or less constant as a function of phantom activity. The relation between acquisition and reconstruction settings and image quality was confirmed in the 99mTc-hydroxymethylene diphosphonate mouse scans. Conclusion: Although developed for small-animal PET, the NEMA NU 4 image quality phantom was found to be useful for small-animal SPECT as well, allowing for objective determination of image quality parameters and showing the tradeoffs between several of these parameters on variation of acquisition and reconstruction settings.

    KW - multi-pinhole

    KW - EWI-22996

    KW - Image quality

    KW - IR-83673

    KW - Small animal

    KW - Single photon emission computed tomography

    KW - NEMA

    U2 - 10.2967/jnumed.110.087114

    DO - 10.2967/jnumed.110.087114

    M3 - Article

    VL - 52

    SP - 1646

    EP - 1653

    JO - Journal of nuclear medicine

    JF - Journal of nuclear medicine

    SN - 0161-5505

    IS - 10

    ER -