Utilizing the Oxygen Reduction Reaction in Particle Impact Electrochemistry: A Step toward Mediator-Free Digital Electrochemical Sensors

Taghi Moazzenzade, Jurriaan Huskens, Serge G. Lemay*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

The current blockade particle impact method opens a route toward highly parallelized single-entity electrochemical assays. An important limitation is, however, that a redox mediator must be present in the sample, which can detrimentally interfere with molecular recognition processes. Dissolved O2 that is naturally present in aqueous solutions under ambient conditions can in principle serve as a suitable mediator via the oxygen reduction reaction (ORR). Here, we demonstrate the validity of this concept by performing current blockade experiments to capture and detect individual microparticles at Pt microelectrodes using solely the ORR. The readout modality is independent of the absolute O2 concentration, allowing operation under varying conditions. We further determine how the trajectories of individual microparticles are influenced by the combination of electrophoresis and electroosmotic flows and how these can be utilized to provide continuous detection of cationic particles in water for environmental monitoring.

Original languageEnglish
Pages (from-to)31265-31270
Number of pages6
JournalACS Omega
Volume8
Issue number34
Early online date15 Aug 2023
DOIs
Publication statusPublished - 29 Aug 2023

Keywords

  • Electrodes
  • Microparticles
  • Oxygen
  • Platinum
  • Redox reactions

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