Abstract
| Original language | English |
|---|---|
| Article number | 121314 |
| Number of pages | 11 |
| Journal | Journal of biomedical optics |
| Volume | 20 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2015 |
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Validation of quantitative attenuation and backscattering coefficient measurements by optical coherence tomography in the concentration-dependent and multiple scattering regime. / Almasian, Mitra; Bosschaart, Nienke ; van Leeuwen, Ton; Faber, Dirk.
In: Journal of biomedical optics, Vol. 20, No. 12, 121314, 2015.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Validation of quantitative attenuation and backscattering coefficient measurements by optical coherence tomography in the concentration-dependent and multiple scattering regime
AU - Almasian, Mitra
AU - Bosschaart, Nienke
AU - van Leeuwen, Ton
AU - Faber, Dirk
N1 - Special Section on Optical Medical Imaging Standards
PY - 2015
Y1 - 2015
N2 - Optical coherence tomography (OCT) has the potential to quantitatively measure optical properties of tissue such as the attenuation coefficient and backscattering coefficient. However, to obtain reliable values for strong scattering tissues, accurate consideration of the effects of multiple scattering and the nonlinear relation between the scattering coefficient and scatterer concentration (concentration-dependent scattering) is required. We present a comprehensive model for the OCT signal in which we quantitatively account for both effects, as well as our system parameters (confocal point spread function and sensitivity roll-off). We verify our model with experimental data from controlled phantoms of monodisperse silica beads (scattering coefficients between 1 and 30 mm−1 and scattering anisotropy between 0.4 and 0.9). The optical properties of the phantoms are calculated using Mie theory combined with the Percus–Yevick structure factor to account for concentration-dependent scattering. We demonstrate excellent agreement between the OCT attenuation and backscattering coefficient predicted by our model and experimentally derived values. We conclude that this model enables us to accurately model OCT-derived parameters (i.e., attenuation and backscattering coefficients) in the concentration-dependent and multiple scattering regime for spherical monodisperse samples.
AB - Optical coherence tomography (OCT) has the potential to quantitatively measure optical properties of tissue such as the attenuation coefficient and backscattering coefficient. However, to obtain reliable values for strong scattering tissues, accurate consideration of the effects of multiple scattering and the nonlinear relation between the scattering coefficient and scatterer concentration (concentration-dependent scattering) is required. We present a comprehensive model for the OCT signal in which we quantitatively account for both effects, as well as our system parameters (confocal point spread function and sensitivity roll-off). We verify our model with experimental data from controlled phantoms of monodisperse silica beads (scattering coefficients between 1 and 30 mm−1 and scattering anisotropy between 0.4 and 0.9). The optical properties of the phantoms are calculated using Mie theory combined with the Percus–Yevick structure factor to account for concentration-dependent scattering. We demonstrate excellent agreement between the OCT attenuation and backscattering coefficient predicted by our model and experimentally derived values. We conclude that this model enables us to accurately model OCT-derived parameters (i.e., attenuation and backscattering coefficients) in the concentration-dependent and multiple scattering regime for spherical monodisperse samples.
U2 - 10.1117/1.JBO.20.12.121314
DO - 10.1117/1.JBO.20.12.121314
M3 - Article
VL - 20
JO - Journal of biomedical optics
JF - Journal of biomedical optics
SN - 1083-3668
IS - 12
M1 - 121314
ER -