Validation of the oxygen desaturation index in the diagnostic workup of obstructive sleep apnea

Timon M. Fabius* (Corresponding Author), Jeffrey R. Benistant, Lindsey Bekkedam, Job van der Palen, Frans H.C. de Jongh, Michiel M. Eijsvogel

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review

    4 Citations (Scopus)
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    Abstract

    Introduction: Obstructive sleep apnea (OSA) is common, and diagnosis requires expensive and laborious testing to assess the apnea hypopnea index (AHI). We performed an analysis to explore the relationship between the oxygen desaturation index (ODI) as measured with pulse oximetry and the AHI in our large portable monitoring (PM) database to find an optimal cutoff value for the ODI in order to be able to exclude AHI ≥ 5 on PM. Methods: Three thousand four hundred thirteen PM recordings were randomly divided into a training set (N = 2281) and a test set (N = 1132). The optimal cutoff for the ODI to exclude an AHI ≥ 5 on PM was determined in the training set and subsequently validated in the test set. Results: Area under the curve of the ODI to exclude an AHI ≥ 5 on PM was 0.997 in the training set and 0.996 in the test set. In the training set, the optimal cutoff to predict an AHI < 5 was an ODI < 5. Using this cutoff in the test set provided a sensitivity of 97.7%, a specificity of 97.0%, a positive predictive value of 99.2%, and a negative predictive value of 91.4%. Conclusion: An ODI < 5 predicts an AHI < 5 with high sensitivity and specificity when measured simultaneously using the same oximeter during PM recording.

    Original languageEnglish
    Pages (from-to)57-63
    Number of pages7
    JournalSleep and Breathing
    Volume23
    Issue number1
    Early online date21 Mar 2018
    DOIs
    Publication statusPublished - Mar 2019

    Keywords

    • UT-Hybrid-D
    • Obstructive sleep apnea
    • Oxygen desaturation index
    • Pulse oximetry
    • Apnea hypopnea index

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