TY - JOUR
T1 - Value of attenuation correction in stress-only myocardial perfusion imaging using CZT-SPECT
AU - van Dijk, J.D.
AU - Mouden, M.
AU - Ottervanger, J.P.
AU - van Dalen, J.A.
AU - Knollema, S.
AU - Slump, C.H.
AU - Jager, P.L.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Background: Attenuation correction (AC) improves the diagnostic outcome of stress-only myocardial perfusion imaging (MPI) using conventional SPECT. Our aim was to determine the value of AC using a cadmium zinc telluride-based (CZT)-SPECT camera.Methods and results: We retrospectively included 107 consecutive patients who underwent stress-optional rest MPI CZT-SPECT/CT. Next, we created three types of images for each patient; (1) only displaying reconstructed data without the CT-based AC (NC), (2) only displaying AC, and (3) with both NC and AC (NC + AC). Next, two experienced physicians visually interpreted these 321 randomized images as normal, equivocal, or abnormal. Image outcome was compared with all hard events over a mean follow-up time of 47.7 ± 9.8 months. The percentage of images interpreted as normal increased from 45% using the NC images to 72% using AC and to 67% using NC + AC images (P < .001). Hard event hazard ratios for images interpreted as normal were not different between using NC and AC (1.01, P = .99), or NC and NC + AC images (0.97, P = .97). Conclusions: AC lowers the need for additional rest imaging in stress-first MPI using CZT-SPECT, while long-term patient outcome remained identical. Use of AC reduces the need for additional rest imaging, decreasing the mean effective dose by up to 1.2 mSv.
AB - Background: Attenuation correction (AC) improves the diagnostic outcome of stress-only myocardial perfusion imaging (MPI) using conventional SPECT. Our aim was to determine the value of AC using a cadmium zinc telluride-based (CZT)-SPECT camera.Methods and results: We retrospectively included 107 consecutive patients who underwent stress-optional rest MPI CZT-SPECT/CT. Next, we created three types of images for each patient; (1) only displaying reconstructed data without the CT-based AC (NC), (2) only displaying AC, and (3) with both NC and AC (NC + AC). Next, two experienced physicians visually interpreted these 321 randomized images as normal, equivocal, or abnormal. Image outcome was compared with all hard events over a mean follow-up time of 47.7 ± 9.8 months. The percentage of images interpreted as normal increased from 45% using the NC images to 72% using AC and to 67% using NC + AC images (P < .001). Hard event hazard ratios for images interpreted as normal were not different between using NC and AC (1.01, P = .99), or NC and NC + AC images (0.97, P = .97). Conclusions: AC lowers the need for additional rest imaging in stress-first MPI using CZT-SPECT, while long-term patient outcome remained identical. Use of AC reduces the need for additional rest imaging, decreasing the mean effective dose by up to 1.2 mSv.
KW - Attenuation correction
KW - CdZnTe
KW - Myocardial perfusion imaging: SPECT
KW - Stress-only
UR - https://www.scopus.com/pages/publications/84954418036
U2 - 10.1007/s12350-015-0374-2
DO - 10.1007/s12350-015-0374-2
M3 - Article
C2 - 26780528
AN - SCOPUS:84954418036
SN - 1071-3581
VL - 24
SP - 395
EP - 401
JO - Journal of nuclear cardiology
JF - Journal of nuclear cardiology
IS - 2
ER -
