Value of Implementation of Strategies to Increase the Adherence of Health Professionals and Cancer Survivors to Guideline-Based Physical Exercise

Janne C. Mewes, Lotte M.G. Steuten, Charlotte IJsbrandy, Maarten J. IJzerman, Willem H. van Harten*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Background: To increase the adherence of health professionals and cancer survivors to evidence-based physical exercise, effective implementation strategies (ISTs) are required. Objectives: To examine to what extent these ISTs provide value for money and which IST has the highest expected value. Methods: The net benefit framework of health economic evaluations is used to conduct a value-of-implementation analysis of nine ISTs. Seven are directed to health professionals and two to cancer survivors. The analysis consists of four steps: 1) analyzing the expected value of perfect implementation (EVPIM); 2) assessing the estimated costs of the various ISTs; 3) comparing the ISTs' costs with the EVPIM; and 4) assessing the total net benefit (TNB) of the ISTs. These steps are followed to identify which strategy has the greatest value. Results: The EVPIM for physical exercise in the Netherlands is €293 million. The total costs for the ISTs range from €34,000 for printed educational materials for professionals to €120 million for financial incentives for patients, and thus all are cost-effective. The TNB of the ISTs that are directed to professionals ranges from €5.7 million for printed educational materials to €30.9 million for reminder systems. Of the strategies that are directed to patients, only the motivational program had a positive net benefit of €100.4 million. Conclusions: All the ISTs for cancer survivors, except for financial incentives, had a positive TNB. The largest improvements in adherence were created by a motivational program for patients, followed by a reminder system for professionals.

Original languageEnglish
Pages (from-to)1336-1344
JournalValue in health
Issue number10
Publication statusPublished - Dec 2017


  • Cancer survivors
  • Expected value of perfect implementation
  • Guideline implementation
  • Implementation research
  • Physical exercise
  • Rehabilitation
  • Value-of-implementation analysis
  • 22/4 OA procedure

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