Abstract
The purpose of this research was to assess the value of systemic inflammatory biomarkers in the detection of acute aortic dissection (AD). Rapid diagnosis and initiation of treatment is pivotal for patients with acute AD. So far, there is no laboratory test to aid the diagnosis. Plasma fibrin D-dimers, white blood cell (WBC) count, C-reactive protein (CRP), and fibrinogen were determined in 64 chest-pain (CP) patients (acute AD, n = 16; pulmonary embolism [PE], n = 16; acute myocardial infarction [AMI], n = 16; non-cardiac CP, n = 16); 32 asymptomatic patients with chronic AD served as a control group. All acute AD patients showed highly elevated D-dimer values that were similar to PE patients (2,238 1,765 μg/l vs. 1,531 837 μg/l, p = 0.15) but significantly higher than in chronic AD, AMI, or CP patients (p < 0.001). The WBC count was significantly increased in patients with acute AD compared with the other groups (p < 0.001); in addition, CRP values differed only non-significantly from PE patients(p = 0.71). There were no differences in the fibrinogen levels between the groups. D-dimers are highly elevated in both acute PE and acute AD. Patients with acute AD show significant systemic inflammatory reactions. Measurement of D-dimers may be a valuable addition to the current diagnostic work-up of patients with suspected AD.
| Original language | English |
|---|---|
| Pages (from-to) | 804-809 |
| Number of pages | 6 |
| Journal | Journal of the American College of Cardiology |
| Volume | 44 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 18 Aug 2004 |
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Value of plasma fibrin D-dimers for detection of acute aortic dissection. / Eggebrecht, Holger; Naber, Christoph K.; Bruch, Christian; Kröger, Knut; Von Birgelen, Clemens; Schmermund, Axel; Wichert, Marc; Bartel, Thomas; Mann, Klaus; Erbel, Raimund.
In: Journal of the American College of Cardiology, Vol. 44, No. 4, 18.08.2004, p. 804-809.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Value of plasma fibrin D-dimers for detection of acute aortic dissection
AU - Eggebrecht, Holger
AU - Naber, Christoph K.
AU - Bruch, Christian
AU - Kröger, Knut
AU - Von Birgelen, Clemens
AU - Schmermund, Axel
AU - Wichert, Marc
AU - Bartel, Thomas
AU - Mann, Klaus
AU - Erbel, Raimund
PY - 2004/8/18
Y1 - 2004/8/18
N2 - The purpose of this research was to assess the value of systemic inflammatory biomarkers in the detection of acute aortic dissection (AD). Rapid diagnosis and initiation of treatment is pivotal for patients with acute AD. So far, there is no laboratory test to aid the diagnosis. Plasma fibrin D-dimers, white blood cell (WBC) count, C-reactive protein (CRP), and fibrinogen were determined in 64 chest-pain (CP) patients (acute AD, n = 16; pulmonary embolism [PE], n = 16; acute myocardial infarction [AMI], n = 16; non-cardiac CP, n = 16); 32 asymptomatic patients with chronic AD served as a control group. All acute AD patients showed highly elevated D-dimer values that were similar to PE patients (2,238 1,765 μg/l vs. 1,531 837 μg/l, p = 0.15) but significantly higher than in chronic AD, AMI, or CP patients (p < 0.001). The WBC count was significantly increased in patients with acute AD compared with the other groups (p < 0.001); in addition, CRP values differed only non-significantly from PE patients(p = 0.71). There were no differences in the fibrinogen levels between the groups. D-dimers are highly elevated in both acute PE and acute AD. Patients with acute AD show significant systemic inflammatory reactions. Measurement of D-dimers may be a valuable addition to the current diagnostic work-up of patients with suspected AD.
AB - The purpose of this research was to assess the value of systemic inflammatory biomarkers in the detection of acute aortic dissection (AD). Rapid diagnosis and initiation of treatment is pivotal for patients with acute AD. So far, there is no laboratory test to aid the diagnosis. Plasma fibrin D-dimers, white blood cell (WBC) count, C-reactive protein (CRP), and fibrinogen were determined in 64 chest-pain (CP) patients (acute AD, n = 16; pulmonary embolism [PE], n = 16; acute myocardial infarction [AMI], n = 16; non-cardiac CP, n = 16); 32 asymptomatic patients with chronic AD served as a control group. All acute AD patients showed highly elevated D-dimer values that were similar to PE patients (2,238 1,765 μg/l vs. 1,531 837 μg/l, p = 0.15) but significantly higher than in chronic AD, AMI, or CP patients (p < 0.001). The WBC count was significantly increased in patients with acute AD compared with the other groups (p < 0.001); in addition, CRP values differed only non-significantly from PE patients(p = 0.71). There were no differences in the fibrinogen levels between the groups. D-dimers are highly elevated in both acute PE and acute AD. Patients with acute AD show significant systemic inflammatory reactions. Measurement of D-dimers may be a valuable addition to the current diagnostic work-up of patients with suspected AD.
UR - http://www.scopus.com/inward/record.url?scp=4143149650&partnerID=8YFLogxK
U2 - 10.1016/j.jacc.2004.04.053
DO - 10.1016/j.jacc.2004.04.053
M3 - Article
VL - 44
SP - 804
EP - 809
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
IS - 4
ER -