Variation of the bone forming ability with the physicochemical properties of calcium phosphate bone substitutes

Rongquan Duan, Davide Barbieri, Xiaoman Luo, Jie Weng, Chongyun Bao, Joost D. De Bruijn, Huipin Yuan (Corresponding Author)

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4 Citations (Scopus)

Abstract

Because of their bioactive properties and chemical similarity to the inorganic component of bone, calcium phosphate (CaP) materials are widely used for bone regeneration. Six commercially available CaP bone substitutes (Bio-Oss, Actifuse, Bi-Ostetic, MBCP, Vitoss and chronOs) as well as two tricalcium phosphate (TCP) ceramics with either a micron-scale (TCP-B) or submicron-scale (TCP-S) surface structure are characterized and their bone forming potential is evaluated in a canine ectopic implantation model. After 12 weeks of implantation in the paraspinal muscle of four beagles, sporadic bone (0.1 ± 0.1%) is observed in two Actifuse implants (2/4), limited bone (2.1 ± 1.4%) in four MBCP implants (4/4) and abundant bone (21.6 ± 4.5%) is formed in all TCP-S implants (4/4). Bone is not observed in any of the Bio-Oss, Bi-Ostetic, Vitoss, chronOs and TCP-B implants (0/4). When correlating the bone forming potential with the physicochemical properties of each material, we observe that the physical characteristics (e.g. grain size and micropore size at the submicron scale) might be the dominant trigger of material directed bone formation via specific mechanotransduction, instead of protein adsorption, surface mineralization and calcium ion release.

Original languageEnglish
Pages (from-to)136-145
Number of pages10
JournalBiomaterials Science
Volume6
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018

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Bone Substitutes
Calcium phosphate
Bone
Phosphates
calcium phosphate
Surface structure
Muscle
Calcium
Ions
Adsorption
Proteins

Cite this

Duan, Rongquan ; Barbieri, Davide ; Luo, Xiaoman ; Weng, Jie ; Bao, Chongyun ; De Bruijn, Joost D. ; Yuan, Huipin. / Variation of the bone forming ability with the physicochemical properties of calcium phosphate bone substitutes. In: Biomaterials Science. 2018 ; Vol. 6, No. 1. pp. 136-145.
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abstract = "Because of their bioactive properties and chemical similarity to the inorganic component of bone, calcium phosphate (CaP) materials are widely used for bone regeneration. Six commercially available CaP bone substitutes (Bio-Oss, Actifuse, Bi-Ostetic, MBCP, Vitoss and chronOs) as well as two tricalcium phosphate (TCP) ceramics with either a micron-scale (TCP-B) or submicron-scale (TCP-S) surface structure are characterized and their bone forming potential is evaluated in a canine ectopic implantation model. After 12 weeks of implantation in the paraspinal muscle of four beagles, sporadic bone (0.1 ± 0.1{\%}) is observed in two Actifuse implants (2/4), limited bone (2.1 ± 1.4{\%}) in four MBCP implants (4/4) and abundant bone (21.6 ± 4.5{\%}) is formed in all TCP-S implants (4/4). Bone is not observed in any of the Bio-Oss, Bi-Ostetic, Vitoss, chronOs and TCP-B implants (0/4). When correlating the bone forming potential with the physicochemical properties of each material, we observe that the physical characteristics (e.g. grain size and micropore size at the submicron scale) might be the dominant trigger of material directed bone formation via specific mechanotransduction, instead of protein adsorption, surface mineralization and calcium ion release.",
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Duan, R, Barbieri, D, Luo, X, Weng, J, Bao, C, De Bruijn, JD & Yuan, H 2018, 'Variation of the bone forming ability with the physicochemical properties of calcium phosphate bone substitutes' Biomaterials Science, vol. 6, no. 1, pp. 136-145. https://doi.org/10.1039/c7bm00717e

Variation of the bone forming ability with the physicochemical properties of calcium phosphate bone substitutes. / Duan, Rongquan; Barbieri, Davide; Luo, Xiaoman; Weng, Jie; Bao, Chongyun; De Bruijn, Joost D.; Yuan, Huipin (Corresponding Author).

In: Biomaterials Science, Vol. 6, No. 1, 01.01.2018, p. 136-145.

Research output: Contribution to journalArticleAcademicpeer-review

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