Vascularization and Angiogenesis in Tissue Engineering: Beyond Creating Static Networks

Jeroen Rouwkema, A. Khademhosseini

Research output: Contribution to journalArticleAcademicpeer-review

132 Citations (Scopus)

Abstract

Engineered tissues need a vascular network to supply cells with nutrients and oxygen after implantation. A network that can connect to the vasculature of the patient after implantation can be included during in vitro culture. For optimal integration, this network needs to be highly organized, including venules, capillaries, and arterioles, to supply all of the cells with sufficient nutrients. Owing to the importance of vascularization for the clinical applicability of tissue engineering, many approaches have been investigated to include an organized vascular network in tissue constructs. This review will give an overview of recent efforts, and will propose future perspectives to engineer the optimal, functional vascular network.
Original languageEnglish
Pages (from-to)733-745
Number of pages11
JournalTrends in biotechnology
Volume34
Issue number9
DOIs
Publication statusPublished - 2016

Fingerprint

Tissue Engineering
Tissue engineering
Nutrients
Blood Vessels
Tissue
Food
Venules
Arterioles
Oxygen
Engineers

Keywords

  • METIS-317642
  • IR-101189

Cite this

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abstract = "Engineered tissues need a vascular network to supply cells with nutrients and oxygen after implantation. A network that can connect to the vasculature of the patient after implantation can be included during in vitro culture. For optimal integration, this network needs to be highly organized, including venules, capillaries, and arterioles, to supply all of the cells with sufficient nutrients. Owing to the importance of vascularization for the clinical applicability of tissue engineering, many approaches have been investigated to include an organized vascular network in tissue constructs. This review will give an overview of recent efforts, and will propose future perspectives to engineer the optimal, functional vascular network.",
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Vascularization and Angiogenesis in Tissue Engineering: Beyond Creating Static Networks. / Rouwkema, Jeroen; Khademhosseini, A.

In: Trends in biotechnology, Vol. 34, No. 9, 2016, p. 733-745.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Vascularization and Angiogenesis in Tissue Engineering: Beyond Creating Static Networks

AU - Rouwkema, Jeroen

AU - Khademhosseini, A.

N1 - Special issue: Biofabrication

PY - 2016

Y1 - 2016

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AB - Engineered tissues need a vascular network to supply cells with nutrients and oxygen after implantation. A network that can connect to the vasculature of the patient after implantation can be included during in vitro culture. For optimal integration, this network needs to be highly organized, including venules, capillaries, and arterioles, to supply all of the cells with sufficient nutrients. Owing to the importance of vascularization for the clinical applicability of tissue engineering, many approaches have been investigated to include an organized vascular network in tissue constructs. This review will give an overview of recent efforts, and will propose future perspectives to engineer the optimal, functional vascular network.

KW - METIS-317642

KW - IR-101189

U2 - 10.1016/j.tibtech.2016.03.002

DO - 10.1016/j.tibtech.2016.03.002

M3 - Article

VL - 34

SP - 733

EP - 745

JO - Trends in biotechnology

JF - Trends in biotechnology

SN - 0167-7799

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