Vascularization Tissue Engineering

Jeroen Rouwkema; N.C. Rivron; Clemens van Blitterswijk

doi:10.1016/j.tibtech.2008.04.009

Vascularization Tissue Engineering

Jeroen Rouwkema, N.C. Rivron, Clemens van Blitterswijk

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Tissue engineering has been an active field of research for several decades now. However, the amount of clinical applications in the field of tissue engineering is still limited. One of the current limitations of tissue engineering is its inability to provide sufficient blood supply in the initial phase after implantation. Insufficient vascularization can lead to improper cell integration or cell death in tissue-engineered constructs. This review will discuss the advantages and limitations of recent strategies aimed at enhancing the vascularization of tissue-engineered constructs. We will illustrate that combining the efforts of different research lines might be necessary to obtain optimal results in the field.

Original language	Undefined
Pages (from-to)	434-441
Number of pages	8
Journal	Trends in biotechnology
Volume	26
Issue number	8
DOIs	https://doi.org/10.1016/j.tibtech.2008.04.009
Publication status	Published - 2008

Keywords

IR-73335
METIS-249939

Access to Document

10.1016/j.tibtech.2008.04.009

Cite this

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title = "Vascularization Tissue Engineering",

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AU - van Blitterswijk, Clemens

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AB - Tissue engineering has been an active field of research for several decades now. However, the amount of clinical applications in the field of tissue engineering is still limited. One of the current limitations of tissue engineering is its inability to provide sufficient blood supply in the initial phase after implantation. Insufficient vascularization can lead to improper cell integration or cell death in tissue-engineered constructs. This review will discuss the advantages and limitations of recent strategies aimed at enhancing the vascularization of tissue-engineered constructs. We will illustrate that combining the efforts of different research lines might be necessary to obtain optimal results in the field.

KW - IR-73335

KW - METIS-249939

U2 - 10.1016/j.tibtech.2008.04.009

DO - 10.1016/j.tibtech.2008.04.009

M3 - Article

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