Vascularization Tissue Engineering

Jeroen Rouwkema, N.C. Rivron, Clemens van Blitterswijk

Research output: Contribution to journalArticleAcademicpeer-review

607 Citations (Scopus)

Abstract

Tissue engineering has been an active field of research for several decades now. However, the amount of clinical applications in the field of tissue engineering is still limited. One of the current limitations of tissue engineering is its inability to provide sufficient blood supply in the initial phase after implantation. Insufficient vascularization can lead to improper cell integration or cell death in tissue-engineered constructs. This review will discuss the advantages and limitations of recent strategies aimed at enhancing the vascularization of tissue-engineered constructs. We will illustrate that combining the efforts of different research lines might be necessary to obtain optimal results in the field.
Original languageUndefined
Pages (from-to)434-441
Number of pages8
JournalTrends in biotechnology
Volume26
Issue number8
DOIs
Publication statusPublished - 2008

Keywords

  • IR-73335
  • METIS-249939

Cite this

Rouwkema, Jeroen ; Rivron, N.C. ; van Blitterswijk, Clemens. / Vascularization Tissue Engineering. In: Trends in biotechnology. 2008 ; Vol. 26, No. 8. pp. 434-441.
@article{6d220152befe4c1d9834beb9546c679b,
title = "Vascularization Tissue Engineering",
abstract = "Tissue engineering has been an active field of research for several decades now. However, the amount of clinical applications in the field of tissue engineering is still limited. One of the current limitations of tissue engineering is its inability to provide sufficient blood supply in the initial phase after implantation. Insufficient vascularization can lead to improper cell integration or cell death in tissue-engineered constructs. This review will discuss the advantages and limitations of recent strategies aimed at enhancing the vascularization of tissue-engineered constructs. We will illustrate that combining the efforts of different research lines might be necessary to obtain optimal results in the field.",
keywords = "IR-73335, METIS-249939",
author = "Jeroen Rouwkema and N.C. Rivron and {van Blitterswijk}, Clemens",
year = "2008",
doi = "10.1016/j.tibtech.2008.04.009",
language = "Undefined",
volume = "26",
pages = "434--441",
journal = "Trends in biotechnology",
issn = "0167-7799",
publisher = "Elsevier",
number = "8",

}

Vascularization Tissue Engineering. / Rouwkema, Jeroen; Rivron, N.C.; van Blitterswijk, Clemens.

In: Trends in biotechnology, Vol. 26, No. 8, 2008, p. 434-441.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Vascularization Tissue Engineering

AU - Rouwkema, Jeroen

AU - Rivron, N.C.

AU - van Blitterswijk, Clemens

PY - 2008

Y1 - 2008

N2 - Tissue engineering has been an active field of research for several decades now. However, the amount of clinical applications in the field of tissue engineering is still limited. One of the current limitations of tissue engineering is its inability to provide sufficient blood supply in the initial phase after implantation. Insufficient vascularization can lead to improper cell integration or cell death in tissue-engineered constructs. This review will discuss the advantages and limitations of recent strategies aimed at enhancing the vascularization of tissue-engineered constructs. We will illustrate that combining the efforts of different research lines might be necessary to obtain optimal results in the field.

AB - Tissue engineering has been an active field of research for several decades now. However, the amount of clinical applications in the field of tissue engineering is still limited. One of the current limitations of tissue engineering is its inability to provide sufficient blood supply in the initial phase after implantation. Insufficient vascularization can lead to improper cell integration or cell death in tissue-engineered constructs. This review will discuss the advantages and limitations of recent strategies aimed at enhancing the vascularization of tissue-engineered constructs. We will illustrate that combining the efforts of different research lines might be necessary to obtain optimal results in the field.

KW - IR-73335

KW - METIS-249939

U2 - 10.1016/j.tibtech.2008.04.009

DO - 10.1016/j.tibtech.2008.04.009

M3 - Article

VL - 26

SP - 434

EP - 441

JO - Trends in biotechnology

JF - Trends in biotechnology

SN - 0167-7799

IS - 8

ER -