TY - JOUR
T1 - Ventricular synchrony is not significantly determined by absolute myocardial perfusion in patients with chronic heart failure
T2 - A 13N-ammonia PET study
AU - Juarez-Orozco, Luis Eduardo
AU - Monroy-Gonzalez, Andrea G.
AU - van der Zant, Friso M.
AU - Hoogvorst, Nick
AU - Slart, Riemer H.J.A.
AU - Knol, Remco J.J.
PY - 2020/12
Y1 - 2020/12
N2 - Background: It is thought that heart failure (HF) patients may benefit from the evaluation of mechanical (dys)synchrony, and an independent inverse relationship between myocardial perfusion and ventricular synchrony has been suggested. We explore the relationship between quantitative myocardial perfusion and synchrony parameters when accounting for the presence and extent of fixed perfusion defects in patients with chronic HF. Methods: We studied 98 patients with chronic HF who underwent rest and stress Nitrogen-13 ammonia PET. Multivariate analyses of covariance were performed to determine relevant predictors of synchrony (measured as bandwidth, standard deviation, and entropy). Results: In our population, there were 43 (44%) women and 55 men with a mean age of 71 ± 9.6 years. The SRS was the strongest independent predictor of mechanical synchrony variables (p <.01), among other considered predictors including: age, sex, body mass index, smoking, diabetes mellitus, dyslipidemia, hypertension, rest myocardial blood flow (MBF), and myocardial perfusion reserve (MPR). Results were similar when considering stress MBF instead of MPR. Conclusions: The existence and extent of fixed perfusion defects, but not the quantitative PET myocardial perfusion parameters (sMBF and MPR), constitute a significant independent predictor of ventricular mechanical synchrony in patients with chronic HF.
AB - Background: It is thought that heart failure (HF) patients may benefit from the evaluation of mechanical (dys)synchrony, and an independent inverse relationship between myocardial perfusion and ventricular synchrony has been suggested. We explore the relationship between quantitative myocardial perfusion and synchrony parameters when accounting for the presence and extent of fixed perfusion defects in patients with chronic HF. Methods: We studied 98 patients with chronic HF who underwent rest and stress Nitrogen-13 ammonia PET. Multivariate analyses of covariance were performed to determine relevant predictors of synchrony (measured as bandwidth, standard deviation, and entropy). Results: In our population, there were 43 (44%) women and 55 men with a mean age of 71 ± 9.6 years. The SRS was the strongest independent predictor of mechanical synchrony variables (p <.01), among other considered predictors including: age, sex, body mass index, smoking, diabetes mellitus, dyslipidemia, hypertension, rest myocardial blood flow (MBF), and myocardial perfusion reserve (MPR). Results were similar when considering stress MBF instead of MPR. Conclusions: The existence and extent of fixed perfusion defects, but not the quantitative PET myocardial perfusion parameters (sMBF and MPR), constitute a significant independent predictor of ventricular mechanical synchrony in patients with chronic HF.
KW - heart failure
KW - mechanical synchrony
KW - myocardial perfusion
KW - Positron emission tomography
UR - http://www.scopus.com/inward/record.url?scp=85056740800&partnerID=8YFLogxK
U2 - 10.1007/s12350-018-01507-9
DO - 10.1007/s12350-018-01507-9
M3 - Article
C2 - 30443751
AN - SCOPUS:85056740800
SN - 1071-3581
VL - 27
SP - 2234
EP - 2242
JO - Journal of nuclear cardiology
JF - Journal of nuclear cardiology
IS - 6
ER -