Versatile fabrication and integration method of optical oxygen sensors in organ-on-chips

Elsbeth G.B.M. Bossink, Juliëtte V.M. Slob, Dorothee Wasserberg, Loes Segerink, Mathieu Odijk

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

Oxygen concentration is an essential parameter in in vitro cell cultures as it affects cell viability, cellular activity, cell differentiation, and can be a measure for cellular response. Organ-on-chip (OoC) devices provide an in vitro cell culture method, aiming to mimic the in vivo situation better than conventional cell culture methods. Oxygen control in these OoC devices is very meaningful especially for organs with inherently large oxygen concentration gradients, such as the gut. Here, we show a versatile fabrication method for optical oxygen sensor patches based on platinum tetrakis (pentafluorophenyl) porphyrin (PtTFPP) in polystyrene (PS). The PtTFPP/PS sensors show a linear Stern Volmer calibration plot. The proposed fabrication method allows abundant design freedom regarding both the sensor patches (size and shape) and integration (site and number of patches) in a typical two-channel OoC device.
Original languageEnglish
Title of host publication2020 IEEE sensors
Place of PublicationPiscataway, NJ
PublisherIEEE
Number of pages4
ISBN (Electronic)978-1-7281-6802-9
ISBN (Print)978-1-7281-6802-9
DOIs
Publication statusPublished - 9 Dec 2020
EventIEEE Sensors 2020 - Virtual Event, Virtual, Rotterdam, Netherlands
Duration: 25 Oct 202028 Oct 2020
https://2020.ieee-sensorsconference.org/

Publication series

NameIEEE SENSORS
PublisherIEEE
Volume2020
ISSN (Print)1930-0395
ISSN (Electronic)2168-9229

Conference

ConferenceIEEE Sensors 2020
CountryNetherlands
CityVirtual, Rotterdam
Period25/10/2028/10/20
Internet address

Keywords

  • Optical oxygen sensor
  • Organ-on-chip
  • Platinum tetrakis (pentafluorophenyl) porphyrin
  • PtTFPP
  • Polystyrene

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