Abstract
Oxygen concentration is an essential parameter in in vitro cell cultures as it affects cell viability, cellular activity, cell differentiation, and can be a measure for cellular response. Organ-on-chip (OoC) devices provide an in vitro cell culture method, aiming to mimic the in vivo situation better than conventional cell culture methods. Oxygen control in these OoC devices is very meaningful especially for organs with inherently large oxygen concentration gradients, such as the gut. Here, we show a versatile fabrication method for optical oxygen sensor patches based on platinum tetrakis (pentafluorophenyl) porphyrin (PtTFPP) in polystyrene (PS). The PtTFPP/PS sensors show a linear Stern Volmer calibration plot. The proposed fabrication method allows abundant design freedom regarding both the sensor patches (size and shape) and integration (site and number of patches) in a typical two-channel OoC device.
| Original language | English |
|---|---|
| Title of host publication | 2020 IEEE sensors |
| Place of Publication | Piscataway, NJ |
| Publisher | IEEE |
| Number of pages | 4 |
| ISBN (Electronic) | 978-1-7281-6802-9 |
| ISBN (Print) | 978-1-7281-6802-9 |
| DOIs | |
| Publication status | Published - 9 Dec 2020 |
| Event | IEEE Sensors 2020 - Virtual Event, Virtual, Rotterdam, Netherlands Duration: 25 Oct 2020 → 28 Oct 2020 https://2020.ieee-sensorsconference.org/ |
Publication series
| Name | IEEE SENSORS |
|---|---|
| Publisher | IEEE |
| Volume | 2020 |
| ISSN (Print) | 1930-0395 |
| ISSN (Electronic) | 2168-9229 |
Conference
| Conference | IEEE Sensors 2020 |
|---|---|
| Country/Territory | Netherlands |
| City | Virtual, Rotterdam |
| Period | 25/10/20 → 28/10/20 |
| Internet address |
Keywords
- 2021 OA procedure
- Organ-on-chip
- Platinum tetrakis (pentafluorophenyl) porphyrin
- PtTFPP
- Polystyrene
- Optical oxygen sensor