TY - JOUR
T1 - Video-based valve motion combined with computational fluid dynamics gives stable and accurate simulations of blood flow in the Realheart total artificial heart
AU - Kelly, Nathaniel S.
AU - McCree, Danny
AU - Fresiello, Libera
AU - Brynedal Ignell, Nils
AU - Cookson, Andrew N.
AU - Najar, Azad
AU - Perkins, Ina Laura
AU - Fraser, Katharine H.
N1 - Funding Information:
This study was partially funded by Scandinavian Real Heart AB. NSK has an EPSRC DTP studentship (Reference: 1944013).
Funding Information:
This study was partially funded by Scandinavian Real Heart AB. NSK has an EPSRC DTP studentship (Reference: 1944013).
Publisher Copyright:
© 2021 The Authors. Artificial Organs published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC
PY - 2022/1
Y1 - 2022/1
N2 - Background: Patients with end-stage, biventricular heart failure, and for whom heart transplantation is not an option, may be given a Total Artificial Heart (TAH). The Realheart® is a novel TAH which pumps blood by mimicking the native heart with translation of an atrioventricular plane. The aim of this work was to create a strategy for using Computational Fluid Dynamics (CFD) to simulate haemodynamics in the Realheart®, including motion of the atrioventricular plane and valves. Methods: The accuracies of four different computational methods for simulating fluid-structure interaction of the prosthetic valves were assessed by comparison of chamber pressures and flow rates with experimental measurements. The four strategies were: prescribed motion of valves opening and closing at the atrioventricular plane extrema; simulation of fluid-structure interaction of both valves; prescribed motion of the mitral valve with simulation of fluid-structure interaction of the aortic valve; motion of both valves prescribed from video analysis of experiments. Results: The most accurate strategy (error in ventricular pressure of 6%, error in flow rate of 5%) used video-prescribed motion. With the Realheart operating at 80 bpm, the power consumption was 1.03 W, maximum shear stress was 15 Pa, and washout of the ventricle chamber after 4 cycles was 87%. Conclusions: This study, the first CFD analysis of this novel TAH, demonstrates that good agreement between computational and experimental data can be achieved. This method will therefore enable future optimisation of the geometry and motion of the Realheart®.
AB - Background: Patients with end-stage, biventricular heart failure, and for whom heart transplantation is not an option, may be given a Total Artificial Heart (TAH). The Realheart® is a novel TAH which pumps blood by mimicking the native heart with translation of an atrioventricular plane. The aim of this work was to create a strategy for using Computational Fluid Dynamics (CFD) to simulate haemodynamics in the Realheart®, including motion of the atrioventricular plane and valves. Methods: The accuracies of four different computational methods for simulating fluid-structure interaction of the prosthetic valves were assessed by comparison of chamber pressures and flow rates with experimental measurements. The four strategies were: prescribed motion of valves opening and closing at the atrioventricular plane extrema; simulation of fluid-structure interaction of both valves; prescribed motion of the mitral valve with simulation of fluid-structure interaction of the aortic valve; motion of both valves prescribed from video analysis of experiments. Results: The most accurate strategy (error in ventricular pressure of 6%, error in flow rate of 5%) used video-prescribed motion. With the Realheart operating at 80 bpm, the power consumption was 1.03 W, maximum shear stress was 15 Pa, and washout of the ventricle chamber after 4 cycles was 87%. Conclusions: This study, the first CFD analysis of this novel TAH, demonstrates that good agreement between computational and experimental data can be achieved. This method will therefore enable future optimisation of the geometry and motion of the Realheart®.
KW - computational fluid dynamics
KW - fluid
KW - hemodynamics
KW - structure interaction
KW - total artificial heart
UR - http://www.scopus.com/inward/record.url?scp=85115148430&partnerID=8YFLogxK
U2 - 10.1111/aor.14056
DO - 10.1111/aor.14056
M3 - Article
C2 - 34460941
AN - SCOPUS:85115148430
SN - 0160-564X
VL - 46
SP - 57
EP - 70
JO - Artificial organs
JF - Artificial organs
IS - 1
ER -