Virus-based nanocarriers for drug delivery

Research output: Contribution to journalArticleAcademicpeer-review

218 Citations (Scopus)

Abstract

New nanocarrier platforms based on natural biological building blocks offer great promises in revolutionalizing medicine. The usage of specific protein cage structures: virus-like particles (VLPs) for drug packaging and targetted delivery is summarized here. Versatile chemical and genetic modifications on the outer surfaces and inner cavities of VLPs facilitate the preparation of new materials that could meet the biocompatibility, solubility and high uptake efficiency requirements for drug delivery. A full evaluation on the toxicity, bio-distribution and immunology of these materials are envisaged to boost their application potentials.
Original languageUndefined
Pages (from-to)811-825
Number of pages14
JournalAdvanced drug delivery reviews
Volume64
Issue number9
DOIs
Publication statusPublished - 2012

Keywords

  • IR-85019
  • METIS-293508

Cite this

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title = "Virus-based nanocarriers for drug delivery",
abstract = "New nanocarrier platforms based on natural biological building blocks offer great promises in revolutionalizing medicine. The usage of specific protein cage structures: virus-like particles (VLPs) for drug packaging and targetted delivery is summarized here. Versatile chemical and genetic modifications on the outer surfaces and inner cavities of VLPs facilitate the preparation of new materials that could meet the biocompatibility, solubility and high uptake efficiency requirements for drug delivery. A full evaluation on the toxicity, bio-distribution and immunology of these materials are envisaged to boost their application potentials.",
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author = "Y. Ma and R.J.M. Nolte and Cornelissen, {Jeroen Johannes Lambertus Maria}",
year = "2012",
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language = "Undefined",
volume = "64",
pages = "811--825",
journal = "Advanced drug delivery reviews",
issn = "0169-409X",
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Virus-based nanocarriers for drug delivery. / Ma, Y.; Nolte, R.J.M.; Cornelissen, Jeroen Johannes Lambertus Maria.

In: Advanced drug delivery reviews, Vol. 64, No. 9, 2012, p. 811-825.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Virus-based nanocarriers for drug delivery

AU - Ma, Y.

AU - Nolte, R.J.M.

AU - Cornelissen, Jeroen Johannes Lambertus Maria

PY - 2012

Y1 - 2012

N2 - New nanocarrier platforms based on natural biological building blocks offer great promises in revolutionalizing medicine. The usage of specific protein cage structures: virus-like particles (VLPs) for drug packaging and targetted delivery is summarized here. Versatile chemical and genetic modifications on the outer surfaces and inner cavities of VLPs facilitate the preparation of new materials that could meet the biocompatibility, solubility and high uptake efficiency requirements for drug delivery. A full evaluation on the toxicity, bio-distribution and immunology of these materials are envisaged to boost their application potentials.

AB - New nanocarrier platforms based on natural biological building blocks offer great promises in revolutionalizing medicine. The usage of specific protein cage structures: virus-like particles (VLPs) for drug packaging and targetted delivery is summarized here. Versatile chemical and genetic modifications on the outer surfaces and inner cavities of VLPs facilitate the preparation of new materials that could meet the biocompatibility, solubility and high uptake efficiency requirements for drug delivery. A full evaluation on the toxicity, bio-distribution and immunology of these materials are envisaged to boost their application potentials.

KW - IR-85019

KW - METIS-293508

U2 - 10.1016/j.addr.2012.01.005

DO - 10.1016/j.addr.2012.01.005

M3 - Article

VL - 64

SP - 811

EP - 825

JO - Advanced drug delivery reviews

JF - Advanced drug delivery reviews

SN - 0169-409X

IS - 9

ER -