Virus-based nanocarriers for drug delivery

Y. Ma; R.J.M. Nolte; Jeroen Johannes Lambertus Maria Cornelissen

doi:10.1016/j.addr.2012.01.005

Virus-based nanocarriers for drug delivery

Y. Ma, R.J.M. Nolte, Jeroen Johannes Lambertus Maria Cornelissen

Research output: Contribution to journal › Article › Academic › peer-review

262 Citations (Scopus)

Abstract

New nanocarrier platforms based on natural biological building blocks offer great promises in revolutionalizing medicine. The usage of specific protein cage structures: virus-like particles (VLPs) for drug packaging and targetted delivery is summarized here. Versatile chemical and genetic modifications on the outer surfaces and inner cavities of VLPs facilitate the preparation of new materials that could meet the biocompatibility, solubility and high uptake efficiency requirements for drug delivery. A full evaluation on the toxicity, bio-distribution and immunology of these materials are envisaged to boost their application potentials.

Original language	Undefined
Pages (from-to)	811-825
Number of pages	14
Journal	Advanced drug delivery reviews
Volume	64
Issue number	9
DOIs	https://doi.org/10.1016/j.addr.2012.01.005
Publication status	Published - 2012

Keywords

IR-85019
METIS-293508

Access to Document

10.1016/j.addr.2012.01.005

Cite this

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title = "Virus-based nanocarriers for drug delivery",

abstract = "New nanocarrier platforms based on natural biological building blocks offer great promises in revolutionalizing medicine. The usage of specific protein cage structures: virus-like particles (VLPs) for drug packaging and targetted delivery is summarized here. Versatile chemical and genetic modifications on the outer surfaces and inner cavities of VLPs facilitate the preparation of new materials that could meet the biocompatibility, solubility and high uptake efficiency requirements for drug delivery. A full evaluation on the toxicity, bio-distribution and immunology of these materials are envisaged to boost their application potentials.",

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AB - New nanocarrier platforms based on natural biological building blocks offer great promises in revolutionalizing medicine. The usage of specific protein cage structures: virus-like particles (VLPs) for drug packaging and targetted delivery is summarized here. Versatile chemical and genetic modifications on the outer surfaces and inner cavities of VLPs facilitate the preparation of new materials that could meet the biocompatibility, solubility and high uptake efficiency requirements for drug delivery. A full evaluation on the toxicity, bio-distribution and immunology of these materials are envisaged to boost their application potentials.

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DO - 10.1016/j.addr.2012.01.005

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