Visible-light spectroscopic optical coherence tomography: applications and technology

Research output: ThesisPhD Thesis - Research UT, graduation UT

Abstract

Optical coherence tomography (OCT) is a non-invasive, medical imaging modality that creates three-dimensional images of tissue, using an interferometer with a broadband source. As the light source in OCT spans multiple wavelengths, spectral analysis of the OCT signal (termed spectroscopic OCT, sOCT) can be employed to retrieve wavelength-dependent properties of tissue. sOCT systems using visible-light sources (vis-sOCT) benefit from shorter wavelengths and higher spectral contrast between the main tissue chromophores than those in the infrared. Vis-sOCT is particularly sensitive to the absorption by hemoglobin since it is more pronounced in the visible wavelength range. Throughout this thesis, we explore multiple applications of vis-sOCT in different multidisciplinary fields, including i) the ex-vivo and in-vivo quantification of total hemoglobin concentrations [tHb] in flowing blood, ii) imaging neovascularization in organ-on-chip models of the retina and the formation of thrombi in a blood vessel on-chip model, and iii) the Leidenfrost dynamics of solid carbon dioxide discs.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • University of Twente
Supervisors/Advisors
  • Bosschaart, Nienke, Supervisor
  • Steenbergen, Wiendelt, Supervisor
Award date21 Sept 2023
Place of PublicationEnschede
Publisher
Print ISBNs978-90-365-5735-1
Electronic ISBNs978-90-365-5736-8
DOIs
Publication statusPublished - Sept 2023

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