Volume and contrast development in the Rose Bengal model of cerebral infarction

D. G. Norris*, E. J. Schneider, J. J. Grome, D. Leibfritz1

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)
3 Downloads (Pure)


The development of the Rose Bengal model of cerebral infarction in the rat is monitored using rapid NMR imaging techniques. The lesion volume, T1, T2, and the apparent diffusion coefficient (ADC) are measured in the time interval between 24 and 168 h postinduction. Volumetric T1-weighted 3D imaging of the lesions produced by this model is shown to have a standard error of about 5% over the first 3 days postinduction, rising to about 15% at 1 week. Both the T1 and T2 contrasts are found to be more durable than those in ADC and are, hence, more suitable for volumetric monitoring over this time period. An elevation in ADC is also observed in tissue outside the lesion and this is interpreted as being caused by the transport of edema away from the lesion.

Original languageEnglish
Pages (from-to)531-538
Number of pages8
JournalMAGMA Magnetic Resonance Materials in Physics, Biology, and Medicine
Issue number4
Publication statusPublished - Dec 1994
Externally publishedYes


  • animal model
  • microthrombotic cortical lesion
  • MRI
  • volumetric imaging


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