Volume and contrast development in the Rose Bengal model of cerebral infarction

D. G. Norris; E. J. Schneider; J. J. Grome; D. Leibfritz1

doi:10.1007/BF01766088

Volume and contrast development in the Rose Bengal model of cerebral infarction

D. G. Norris^*, E. J. Schneider, J. J. Grome, D. Leibfritz1

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

The development of the Rose Bengal model of cerebral infarction in the rat is monitored using rapid NMR imaging techniques. The lesion volume, T₁, T₂, and the apparent diffusion coefficient (ADC) are measured in the time interval between 24 and 168 h postinduction. Volumetric T₁-weighted 3D imaging of the lesions produced by this model is shown to have a standard error of about 5% over the first 3 days postinduction, rising to about 15% at 1 week. Both the T₁ and T₂ contrasts are found to be more durable than those in ADC and are, hence, more suitable for volumetric monitoring over this time period. An elevation in ADC is also observed in tissue outside the lesion and this is interpreted as being caused by the transport of edema away from the lesion.

Original language	English
Pages (from-to)	531-538
Number of pages	8
Journal	MAGMA Magnetic Resonance Materials in Physics, Biology, and Medicine
Volume	2
Issue number	4
DOIs	https://doi.org/10.1007/BF01766088
Publication status	Published - Dec 1994
Externally published	Yes

Keywords

animal model
microthrombotic cortical lesion
MRI
volumetric imaging

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title = "Volume and contrast development in the Rose Bengal model of cerebral infarction",

abstract = "The development of the Rose Bengal model of cerebral infarction in the rat is monitored using rapid NMR imaging techniques. The lesion volume, T1, T2, and the apparent diffusion coefficient (ADC) are measured in the time interval between 24 and 168 h postinduction. Volumetric T1-weighted 3D imaging of the lesions produced by this model is shown to have a standard error of about 5% over the first 3 days postinduction, rising to about 15% at 1 week. Both the T1 and T2 contrasts are found to be more durable than those in ADC and are, hence, more suitable for volumetric monitoring over this time period. An elevation in ADC is also observed in tissue outside the lesion and this is interpreted as being caused by the transport of edema away from the lesion.",

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author = "Norris, {D. G.} and Schneider, {E. J.} and Grome, {J. J.} and D. Leibfritz1",

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T1 - Volume and contrast development in the Rose Bengal model of cerebral infarction

AU - Norris, D. G.

AU - Schneider, E. J.

AU - Grome, J. J.

AU - Leibfritz1, D.

PY - 1994/12

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N2 - The development of the Rose Bengal model of cerebral infarction in the rat is monitored using rapid NMR imaging techniques. The lesion volume, T1, T2, and the apparent diffusion coefficient (ADC) are measured in the time interval between 24 and 168 h postinduction. Volumetric T1-weighted 3D imaging of the lesions produced by this model is shown to have a standard error of about 5% over the first 3 days postinduction, rising to about 15% at 1 week. Both the T1 and T2 contrasts are found to be more durable than those in ADC and are, hence, more suitable for volumetric monitoring over this time period. An elevation in ADC is also observed in tissue outside the lesion and this is interpreted as being caused by the transport of edema away from the lesion.

AB - The development of the Rose Bengal model of cerebral infarction in the rat is monitored using rapid NMR imaging techniques. The lesion volume, T1, T2, and the apparent diffusion coefficient (ADC) are measured in the time interval between 24 and 168 h postinduction. Volumetric T1-weighted 3D imaging of the lesions produced by this model is shown to have a standard error of about 5% over the first 3 days postinduction, rising to about 15% at 1 week. Both the T1 and T2 contrasts are found to be more durable than those in ADC and are, hence, more suitable for volumetric monitoring over this time period. An elevation in ADC is also observed in tissue outside the lesion and this is interpreted as being caused by the transport of edema away from the lesion.

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KW - MRI

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Volume and contrast development in the Rose Bengal model of cerebral infarction

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