What is the Place for Uricosuric Agents in Gout Management?

The auto-inflammatory rheumatic disorder gout is a worldwide problem [1]. It causes pain and loss of function when inadequately treated, leading to high costs and loss of productivity, income, and quality of life [1]. Gout is characterized by hyperuricemia and arousal of the NLRP3 (nucleotide-binding domain, leucine-rich repeat-containing proteins) inflammasome resulting in inflammatory arthritis and soft tissue rheumatism due to deposition of monosodium urate (MSU) crystals in joints and soft tissues around [2]. The clinical presentation of gout can be misleading, and other diseases can present in similar ways. In the elderly, gout is often not diagnosed as it frequently presents in the hands of elderly slim women and men [3]. The article focuses the gout management with particular attention to the uricosuric agents. Discussing anti-inflammatory medications details is our study limitation.