TY - JOUR
T1 - White matter integrity and depressive symptoms in cerebral small vessel disease
T2 - The RUN DMC study
AU - van Uden, Ingeborg W.M.
AU - Tuladhar, Anil M.
AU - de Laat, Karlijn F.
AU - van Norden, Anouk G.W.
AU - Norris, David G.
AU - van Dijk, Ewoud J.
AU - Tendolkar, Indira
AU - de Leeuw, Frank-Erik
N1 - Funding Information:
F.E.d.L and E.J.v.D. have received personal fellowships from the Dutch Brain Foundation ( H04-12; F2009(1)-16 ). This study was supported by a clinical fellowship from the Dutch Organization for Scientific Research ( 40-00703-97-07197 ), the ‘ Internationale Stichting Alzheimer Onderzoek ’ (grant number 08510), and a VIDI innovational grant from Dutch Organization for Scientific Research (grant 016.126.351).
Publisher Copyright:
© 2015 American Association for Geriatric Psychiatry.
PY - 2015/5/1
Y1 - 2015/5/1
N2 - Objective: Depressive symptoms are common in elderly with cerebral small vessel disease (SVD). As not every individual with SVD experiences depressive symptoms, other factors might play a role. We therefore investigated the white matter (WM) integrity of the white matter tracts in elderly with depressive symptoms, independent of global cognitive function, by applying the tract-based spatial statistics (TBSS).Design: Prospective cohort study with cross-sectional baseline data.Setting: Radboud University Nijmegen Medical Centre, The Netherlands.Participants: 438 individuals aged between 50-85 years, with SVD without dementia.Measurements: Diffusion tensor imaging parameters and depressive symptoms, assessed with the Center for Epidemiologic Studies Depression Scale.Results: Compared with non-depressed participants (N = 287), those with depressive symptoms (N = 151) had lower fractional anisotropy in the genu and body of the corpus callosum, bilateral inferior fronto-occipital fasciculus, uncinate fasciculus, and corona radiata. These differences disappeared after adjustment for white matter hyperintensities (WMH) and lacunar infarcts. Mean-, axial-and radial diffusivity were higher in these areas in participants with depressive symptoms. After additional adjustment for WMH and lacunar infarcts, the changes observed in radial diffusivity also disappeared. Adding global cognition as confounding variable altered the diffusion parameters only slightly.Conclusion: This study indicates that elderly with depressive symptoms show a lower WM integrity, independent of global cognitive function, and that the presence of SVD is mostly responsible, affecting the fronto-subcortical regions and hereby disrupting the neural circuitry involved in mood regulation.
AB - Objective: Depressive symptoms are common in elderly with cerebral small vessel disease (SVD). As not every individual with SVD experiences depressive symptoms, other factors might play a role. We therefore investigated the white matter (WM) integrity of the white matter tracts in elderly with depressive symptoms, independent of global cognitive function, by applying the tract-based spatial statistics (TBSS).Design: Prospective cohort study with cross-sectional baseline data.Setting: Radboud University Nijmegen Medical Centre, The Netherlands.Participants: 438 individuals aged between 50-85 years, with SVD without dementia.Measurements: Diffusion tensor imaging parameters and depressive symptoms, assessed with the Center for Epidemiologic Studies Depression Scale.Results: Compared with non-depressed participants (N = 287), those with depressive symptoms (N = 151) had lower fractional anisotropy in the genu and body of the corpus callosum, bilateral inferior fronto-occipital fasciculus, uncinate fasciculus, and corona radiata. These differences disappeared after adjustment for white matter hyperintensities (WMH) and lacunar infarcts. Mean-, axial-and radial diffusivity were higher in these areas in participants with depressive symptoms. After additional adjustment for WMH and lacunar infarcts, the changes observed in radial diffusivity also disappeared. Adding global cognition as confounding variable altered the diffusion parameters only slightly.Conclusion: This study indicates that elderly with depressive symptoms show a lower WM integrity, independent of global cognitive function, and that the presence of SVD is mostly responsible, affecting the fronto-subcortical regions and hereby disrupting the neural circuitry involved in mood regulation.
KW - Depressive symptoms
KW - DTI
KW - Elderly
KW - Small vessel disease
KW - TBSS
KW - 2023 OA procedure
UR - http://www.scopus.com/inward/record.url?scp=84928212803&partnerID=8YFLogxK
U2 - 10.1016/j.jagp.2014.07.002
DO - 10.1016/j.jagp.2014.07.002
M3 - Article
C2 - 25151438
SN - 1064-7481
VL - 23
SP - 525
EP - 535
JO - American journal of geriatric psychiatry
JF - American journal of geriatric psychiatry
IS - 5
ER -