TY - JOUR
T1 - White matter integrity in small vessel disease is related to cognition
AU - Tuladhar, Anil M.
AU - van Norden, Anouk G.W.
AU - de Laat, Karlijn F.
AU - Zwiers, Marcel P.
AU - van Dijk, Ewoud J.
AU - Norris, David G.
AU - de Leeuw, Frank-Erik
N1 - Funding Information:
F.E.d.L and E.J.v.D.: personal fellowships Dutch Brain Foundation ( H04-12 ; F2009(1)-16 ); clinical fellowship Netherlands Organization Scientific Research ( 40-00703-97-07197 ); F.E.d.L. received a Vidi innovational grant from the Netherlands Organization for Scientific Research (grant number 016.126.351 ). This work was also supported by the ‘Internationale Stichting Alzheimer Onderzoek’ .
PY - 2015
Y1 - 2015
N2 - Cerebral small vessel disease, including white matter hyperintensities (WMH) and lacunes of presumed vascular origin, is common in elderly people and is related to cognitive impairment and dementia. One possible mechanism could be the disruption of white matter tracts (both within WMH and normal-appearing white matter) that connect distributed brain regions involved in cognitive functions. Here, we investigated the relation between microstructural integrity of the white matter and cognitive functions in patients with small vessel disease. The Radboud University Nijmegen Diffusion tensor and Magnetic resonance Cohort study is a prospective cohort study among 444 independently living, non-demented elderly with cerebral small vessel disease, aged between 5500 and 85 years. All subjects underwent magnetic resonance imaging and diffusion tensor imaging scanning and an extensive neuropsychological assessment. We showed that loss of microstructural integrity of the white matter at specific locations was related to specific cognitive disturbances, which was mainly located in the normal-appearing white matter (p < 0.05, FWE-corrected for multiple comparisons). The microstructural integrity in the genu and splenium showed the highest significant relation with global cognitive function and executive functions, in the cingulum bundle with verbal memory performance. Associations between diffusion tensor imaging parameters and most cognitive domains remained present after adjustment for WMH and lacunes. In conclusion, cognitive disturbances in subjects with cerebral small vessel disease are related to microstructural integrity of multiple white matter fibers (within WMH and normal-appearing white matter) connecting different cortical and subcortical regions.
AB - Cerebral small vessel disease, including white matter hyperintensities (WMH) and lacunes of presumed vascular origin, is common in elderly people and is related to cognitive impairment and dementia. One possible mechanism could be the disruption of white matter tracts (both within WMH and normal-appearing white matter) that connect distributed brain regions involved in cognitive functions. Here, we investigated the relation between microstructural integrity of the white matter and cognitive functions in patients with small vessel disease. The Radboud University Nijmegen Diffusion tensor and Magnetic resonance Cohort study is a prospective cohort study among 444 independently living, non-demented elderly with cerebral small vessel disease, aged between 5500 and 85 years. All subjects underwent magnetic resonance imaging and diffusion tensor imaging scanning and an extensive neuropsychological assessment. We showed that loss of microstructural integrity of the white matter at specific locations was related to specific cognitive disturbances, which was mainly located in the normal-appearing white matter (p < 0.05, FWE-corrected for multiple comparisons). The microstructural integrity in the genu and splenium showed the highest significant relation with global cognitive function and executive functions, in the cingulum bundle with verbal memory performance. Associations between diffusion tensor imaging parameters and most cognitive domains remained present after adjustment for WMH and lacunes. In conclusion, cognitive disturbances in subjects with cerebral small vessel disease are related to microstructural integrity of multiple white matter fibers (within WMH and normal-appearing white matter) connecting different cortical and subcortical regions.
KW - Cerebral small vessel disease
KW - Cognition
KW - Tract-based spatial statistics
KW - White matter integrity
UR - http://www.scopus.com/inward/record.url?scp=84923382648&partnerID=8YFLogxK
U2 - 10.1016/j.nicl.2015.02.003
DO - 10.1016/j.nicl.2015.02.003
M3 - Article
C2 - 25737960
SN - 2213-1582
VL - 7
SP - 518
EP - 524
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
ER -