X-Ray-Guided Robotic Platform for Remote Control of Untethered Magnetic Robots Targeting Blood Clots in the Iliac Artery

Leendert-Jan W. Ligtenberg, Luuc de Jongh, H. Remco Liefers, Dorothee Wasserberg, Emily A.M. Klein Rot, Doron Ben Ami, Udi Sadeh, Roger M. Lomme, Gabriëlle G.M. Tuijthof, Oded Shoseyov, Pascal Jonkheijm, Michiel Warlé, Islam S.M. Khalil

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

To date, the deployment of untethered magnetic robots (UMRs), activated by rotating permanent magnets, has been limited to controlled settings that do not replicate the dynamic conditions encountered in vivo. This study addresses this gap by exploring the challenges associated with transitioning UMRs from artificial environments to more realistic ex vivo scenarios, aiming to enhance their adaptability and functionality in dynamic physiological conditions. Initially, we develop an ex vivo endovascular thrombosis model in the iliac artery, facilitating the evaluation of clot removal through mechanical or chemical means. Subsequently, we deploy millimeter-sized bio-compatible UMRs and maneuver them toward blood clots using an X-ray-guided robotic platform. This demonstration showcases the operator’s adept control in directing the UMRs precisely toward the blood clot, effectively engaging with it to reinstate blood flow. Utilizing cone-beam computed tomography scans for volume reconstruction of the clot (initial volume of 21.8 mm3 ) at specific time points, we illustrate that a significant volume reduction of 16% can be accomplished in under 30 minutes, all without the use of thrombolytic agents.
Original languageEnglish
Title of host publication2024 10th IEEE/RAS-EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob)
Place of PublicationPiscataway, NJ
PublisherIEEE
Pages526-531
Number of pages6
ISBN (Electronic)979-8-3503-8652-3
ISBN (Print)979-8-3503-8653-0
DOIs
Publication statusPublished - 23 Oct 2024

Publication series

NameProceedings IEEE RAS/EMBS International Conference for Biomedical Robotics and Biomechatronics (BioRob)
PublisherIEEE
Number10
Volume2024
ISSN (Print)2155-1774
ISSN (Electronic)2155-1782

Keywords

  • 2024 OA procedure

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